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May 25, 1918


JAMA. 1918;70(21):1562-1563. doi:10.1001/jama.1918.02600210052028

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To the Editor:  —Many have gained the impression that arsphenamin is a severely toxic spirocheticide. I believe that none of the American preparations are as toxic as was the German-made salvarsan. Many physicians have used the American products in our laboratories, and have found the reactions fewer and lighter than were formerly noticed with the German-made salvarsan. These deductions are made from several thousand treatments with the German salvarsan and the American-made salvarsan and arsenobenzol. An unfortunate feature is that many physicians have substituted other forms of antisyphilitic treatment, with the result that the patients do not have such an efficient destruction of spirochetes as they did with the use of salvarsan. When a death or severe reaction follows the use of one of these drugs, it is reported both in the public and in the medical press, but very little is said of the thousands of favorable results.Occasionally

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