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Article
July 20, 1918

TRENCH FEVERA REPORT OF CLINICAL OBSERVATIONS AND RESEARCH AS TO THE ETIOLOGY, PATHOLOGY, PROPHYLAXIS AND TREATMENT OF TRENCH FEVER AMONG TROOPS

Author Affiliations

HAMPSTEAD, ENGLAND

JAMA. 1918;71(3):188-193. doi:10.1001/jama.1918.26020290008009d

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Abstract

Experimental Work  We now turn to our experimental work, undertaken, first, to determine the mode of transmission of trench fever.

MODE OF TRANSMISSION  That the disease was transmissible from man to man was shown by McNee and his fellow workers when they passed on the infection by means of the syringe, injecting the blood from a trench fever patient into a healthy man. We have confirmed this observation on two occasions. The incubation period in the two cases varied considerably, apparently with the stage of the disease at which the patient had arrived from whom the infected blood was obtained.McNee further adduced evidence that the infective agent was to be found in the blood corpuscles themselves, and that, even when the blood was laked, the virus would not pass through a filter. Our attempts to confirm or refute this have so far proved inconclusive, for the laked blood used

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