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September 21, 1918

SYMPOSIUM ON DISEASES DUE TO DEFICIENCIES IN NUTRITION

JAMA. 1918;71(12):937-965. doi:10.1001/jama.1918.02600380001001
Abstract

THE "VITAMIN" HYPOTHESIS AND THE DISEASES REFERABLE TO FAULTY DIET †  E. V. McCOLLUM, Ph.D.BALTIMOREThe studies of the past decade have revealed the fact that the adequate diet of the higher animals must contain protein of the type known as "complete," by which we mean a protein yielding all the amino-acids that are required in the nutrition of an animal. It must contain, in the form of suitable salts, at least nine of the inorganic elements, namely, calcium, magnesium, sodium, potassium, iron, chlorin, iodin, phosphorus and sulphur. The sulphur must be in organic combination in the form of the amino-acid cystin. The diet must supply a suitable quota of energy in the form of protein, carbohydrates and fats, and must, in addition, contain certain substances of unknown chemical nature, to which Funk gave the name "vitamins." There are still differences of opinion concerning the probable number of

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