In Reply Drs Stöllberger and Schneider raise a number of questions about our article. First, with regard to baseline patient characteristics, as stated in the Results section, there were no significant differences in principal baseline characteristics between the groups.
Second, the number of patient-years in Table 2 varies between end points because cumulative patient-years for each row were determined by the time to first event. In the case of the primary end point, the first event could be any component of the composite, whereas the individual rows would only include patients experiencing the specific outcome listed, thus allowing for small variations in the denominator.
Reddy VY, Holmes D. Left Atrial Appendage Closure for Atrial Fibrillation—Reply. JAMA. 2015;313(10):1057-1058. doi:10.1001/jama.2015.0685