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Article
November 2, 1918

PATHOLOGIC SIMILARITY BETWEEN PNEUMONIA OF BUBONIC PLAGUE AND OF PANDEMIC INFLUENZA

Author Affiliations

Professor of Pathology, University and Bellevue Hospital Medical College; Director of Laboratories, Bellevue and Allied Hospitals NEW YORK

JAMA. 1918;71(18):1482-1485. doi:10.1001/jama.1918.26020440007009e
Abstract

Since the commencement of the present epidemic of influenza in New York City I have had occasion to investigate by necropsy at the Willard Parker and Bellevue hospitals twenty cases of death from pneumonia occurring in the course of this remarkable infection. The changes in the lungs are those of a variety of confluent lobular exudative and hemorrhagic pneumonia in which the naked eye and microscopic features bear such a resemblance to the lesions in the pneumonic variety of bubonic plague as to provide an interesting study in similarities. There are, however, several features which serve as differential safeguards in separating the two diseases on anatomic grounds. If these should be eliminated or projected into the background—as not infrequently they are—then, indeed, the sum of the reactions of the pulmonary tissues to the prevailing infection is so nearly equivalent to that of pneumonic plague as described and depicted by investigators

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