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Article
December 28, 1918

IS INFLUENZA DUE TO A FILTRABLE VIRUS?

JAMA. 1918;71(26):2154-2155. doi:10.1001/jama.1918.02600520040012
Abstract

The primary cause of influenza, in accordance with the facts as we now have them, is an unknown agent that prepares the way for secondary infections of the respiratory tract. Is this unknown agent a filtrable virus? The results of experiments just reported to the Academy of Sciences at Paris appear to indicate that it is. Nicolle and Le Bailly1 inoculated monkeys (M. cynomolgus) with the bronchial secretions of patients in the early stages of typical influenza. One monkey, which received the unfiltered secretions under the conjunctiva near the papilla and into the nose, came down on the sixth day with a fever that lasted three days. The same secretion, diluted ten times with salt solution and filtered through a Chamberland candle (L 2) under a pressure of from 30 to 40 cm. of mercury, was injected subcutaneously into a healthy man, who fell sick on the sixth day

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