The entrance of various micro-organisms into the body, particularly when their invasion is localized in such ways as to give rise to septic inflammations, is attended by well recognized, pronounced reactions. These are varied and may include fever, loss of weight and leukocytosis, along with marked disturbances in nitrogenous metabolism. Ordinarily it is assumed that this untoward response is due to the toxins or other ill defined and undefined products of the invading bacteria—a specific reaction. Thus in such types of septic inflammation as septicemia, peritonitis and pneumonia there is in addition to more familiar clinical manifestations a definite rise in the nonprotein and urea nitrogen of the blood.1 Some cases show a great rise above normal (more than 100 mg. of nonprotein nitrogen per hundred c.c. of blood), without evidence of kidney lesions sufficiently severe to indicate retention of metabolites as the cause of the high figures cited.
THE METABOLISM OF NONSPECIFIC INFLAMMATORY PROCESSES. JAMA. 1919;72(4):277-278. doi:10.1001/jama.1919.02610040043020