To the Editor A large randomized clinical trial,1 which was a substudy of the Perioperative Ischemia Evaluation-2 (POISE-2) trial,2 reported that among patients undergoing major noncardiac surgery, perioperative use of aspirin or clonidine did not reduce the risk of acute kidney injury. Aspirin actually increased the risk of major bleeding and clonidine increased the risk of hypotension. We have several comments and concerns.
Sun J, Liu H. Perioperative Treatment With Aspirin or Clonidine and Risk of Acute Kidney Injury. JAMA. 2015;313(11):1166. doi:10.1001/jama.2015.1055