In Reply Drs Sun and Liu are concerned that the risk of major bleeding in POISE-2 (ie, 3.8% in the aspirin placebo group) does not reflect the real-world experience because a study that used the NSQIP database reported a 0.8% risk of major perioperative bleeding.1 There were, however, substantial differences in the populations and bleeding definitions between these studies.
Devereaux PJ, Sessler DI, Garg AX, for the POISE-2 Investigators. Perioperative Treatment With Aspirin or Clonidine and Risk of Acute Kidney Injury—Reply. JAMA. 2015;313(11):1166-1167. doi:10.1001/jama.2015.1061