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Comment & Response
March 17, 2015

Perioperative Treatment With Aspirin or Clonidine and Risk of Acute Kidney Injury—Reply

Author Affiliations
  • 1Population Health Research Institute, Hamilton, Ontario, Canada
  • 2Cleveland Clinic, Cleveland, Ohio
  • 3Western University, London, Ontario, Canada
JAMA. 2015;313(11):1166-1167. doi:10.1001/jama.2015.1061

In Reply Drs Sun and Liu are concerned that the risk of major bleeding in POISE-2 (ie, 3.8% in the aspirin placebo group) does not reflect the real-world experience because a study that used the NSQIP database reported a 0.8% risk of major perioperative bleeding.1 There were, however, substantial differences in the populations and bleeding definitions between these studies.

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