[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 50.16.107.222. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 566
Citations 0
Lab Reports
April 7, 2015

Nanoparticle Delivery Approach Targets Atherosclerotic Plaques

JAMA. 2015;313(13):1305. doi:10.1001/jama.2015.2440

A promising new strategy against atherosclerosis uses nanoparticles to deliver a peptide fragment of annexin A1 (Ac2-26), a glucocorticoid-regulated protein that helps resolve inflammation, to arterial plaques (Fredman G et al. Sci Transl Med. 2015;7[275]:275ra20). The nanoparticles loaded with Ac2-26 are coated with peptides that target atherosclerotic lesions by binding to type IV collagen, a component of the basement membrane that becomes exposed at sites of vascular injury.

First Page Preview View Large
First page PDF preview
First page PDF preview
×