[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 875
Citations 0
Lab Reports
April 7, 2015

Role of Genes in Obesity and Body Fat Distribution

JAMA. 2015;313(13):1305. doi:10.1001/jama.2015.2858

By analyzing genetic samples from 224 459 individuals, researchers identified 49 genomic loci associated with waist-to-hip ratio (WHR), 33 of which are novel (Shungin D et al. Nature. 2015;518[7538]:187-196). Of these 49 loci, 19 showed significant sex-specific differences, suggesting that genetic regulation of fat distribution is sexually dimorphic. These genes influence body fat distribution by affecting fat cell development, blood vessel formation, transcriptional regulation, and insulin resistance.

First Page Preview View Large
First page PDF preview
First page PDF preview