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Comment & Response
April 7, 2015

Low vs High Glycemic Index Diet

Author Affiliations
  • 1Charles Perkins Centre, University of Sydney, Sydney, Australia
  • 2Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
  • 3IEL-Nutritional Epidemiology, University of Bonn, Bonn, Germany
JAMA. 2015;313(13):1371-1372. doi:10.1001/jama.2015.2078

To the Editor In the OmniCarb randomized clinical trial, Dr Sacks and colleagues1 concluded that a 5-week, low glycemic index version of the Dietary Approaches to Stop Hypertension diet did not improve insulin sensitivity or cardiovascular risk factors compared with a higher glycemic index diet.

We are concerned that the duration of the trial was too short. Longer 12- to 26-week studies have demonstrated that low glycemic index diets progressively enhance glycemic control2 and insulin sensitivity.3 High-density lipoprotein (HDL) cholesterol level can increase while patients are on low glycemic index diets over time (approximately 10 weeks).4 Weight loss maintenance and levels of low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) also were improved in overweight and obese participants in the Diet, Obesity, and Genes (DIOGENES) study (26 weeks).5

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