September 27, 1919


JAMA. 1919;73(13):984-985. doi:10.1001/jama.1919.02610390036012

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Although the experimental demonstration of passive anaphylaxis has been clearly established by Nicolle, Otto, Friedmann, Richet and others, I wish to call attention to its importance in actual practice and suggest the necessity of including, in the routine examination of a prospective donor for blood transfusion, questions relative to the various anaphylactic manifestations.

REPORT OF CASE  H. T., man, aged 35, waiter, white, born in Greece, who had been five years in this country, underwent blood transfusion for primary anemia. He had never had asthma, hayfever, bronchitis, urticaria, angioneurotic edema, or any other condition which might indicate a hypersensitiveness to some foreign protein. The family history was negative.Two weeks after receiving 600 c.c. of blood, the patient left his home and went for a carriage ride in Central Park; almost immediately on entering the open carriage, he experienced some difficulty in breathing which within five minutes developed into a

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