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Article
November 15, 1919

A NEW GERMICIDE FOR USE IN THE GENITO-URINARY TRACT: "MERCUROCHROME-220"PRELIMINARY REPORT OF EXPERIMENTAL AND CLINICAL STUDIES

Author Affiliations

BALTIMORE

From the James Buchanan Brady Urological Institute, Johns Hopkins Hospital, with the aid of funds granted by the Interdepartmental Social Hygiene Board for research in the prevention and cure of venereal diseases.

JAMA. 1919;73(20):1483-1491. doi:10.1001/jama.1919.02610460001001
Abstract

During the past two years the research work in the laboratories of the James Buchanan Brady Urological Institute has been given over largely to the study of antiseptics with a view particularly to the development of drugs applicable to the genito-urinary tract. Attention was first directed to internal antiseptics, since Hinman1 had previously shown in our laboratories the questionable value of hexamethylenamin. Starting with the remarkable selective activity of the kidneys on phenolsulphonephthalein, as shown by the work of Abel and Rowntree2 and developed as a functional test in our clinic, we tried to attach other chemical agents to phenolsulphonephthalein and thus produce an effective internal urinary antiseptic. Some interesting drugs were produced and studied by Davis and one of us (E. C. W.3). The war interrupted these studies, but the urgent need of really effective antiseptics for local use in the genito-urinary tract induced us later

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