The science of pathology is still far from formulating an entirely satisfactory hypothesis for the genesis of all forms of nephritis. It is known, of course, that incident to the attempts of the kidney to eliminate certain substances like the salts of mercury or uranium or several other metals, a tubular nephritis of varying intensity may arise; and the acute injury may subsequently become chronic in its manifestations. There is considerable justification for the belief that the reaction of the secreted urine, which in turn is dependent on the nature of the food intake, is not without influence on the behavior of the kidney cells under secretory stress. Usually, however, the etiology of nephritic changes is sought in some foreign factor, such as the inorganic possibilities just cited, or nephrotoxins or nephrolysins assumed to arise within the organism itself.
Although the alleged "strain" of eliminating a large quantity of those
HIGH PROTEIN DIETS AND NEPHRITIS. JAMA. 1920;74(2):107-108. doi:10.1001/jama.1920.02620020039019