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January 31, 1920


JAMA. 1920;74(5):326-327. doi:10.1001/jama.1920.02620050034015

Normally, the urine of the adult male never contains creatin, although the closely related substance creatinin is a never-failing component of the urine as well as of the blood. Healthy women excrete creatin at times.4 Infants and children, on the other hand, exhibit a creatinuria regularly on normal diets and under normal conditions of health. The reason for this peculiarity of metabolism in the adolescent period has never been discovered, although various hypotheses have been advanced in explanation. Thus it has been suggested that creatinuria is associated with acidosis. These two phenomena doubtless are concurrent at times; yet this fact does not demonstrate a causal relation between them. It would be difficult to imagine that the acid-base equilibrium, on the upset of which a true acidosis in the body depends, should be so continuously disturbed as the normal continued output of urinary creatin in childhood would demand. There is

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