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February 14, 1920


JAMA. 1920;74(7):462. doi:10.1001/jama.1920.02620070030013

There are circumstances in which the vigorous action of adequate quantities of quinin in the circulation is highly desirable. The alkaloid itself is rather insoluble; but some of the salts of quinin are fairly soluble, and are absorbed with considerable readiness from the gastro-intestinal canal. The Pharmacology of Useful Drugs,1 issued by the American Medical Association, makes it seem probable that too much importance has been attached to the influence of the degree of solubility of the salts of quinin on their absorption, and too little attention to the selective capacity of the gastro-intestinal tract for absorbing them. In the United States, in contrast with European countries, quinin sulphate is the salt generally prescribed, although the hydrochlorate is decidedly more soluble and ought to be preferred. However that may be, numerous endeavors have been made to secure more effective quinin therapy, particularly in malaria, by modes of administration other

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