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February 21, 1920


JAMA. 1920;74(8):543. doi:10.1001/jama.1920.02620080045025

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To the Editor:  —In a recent editorial comment (The Journal, Jan. 24, 1920, p. 252), reference was made to Major J. R. Goodall's paper on "The Subcutaneous Method of Vaccination," under the caption, "Vaccination Without Scar." The experiment recorded by Goodall in his paper does not give exact information, which is necessary before any conclusions can be drawn. Six thousand individuals were each given, subcutaneously, from one quarter to three quarters of the contents of a capillary tube of vaccine with sufficient water added to make 1 c.c. The local reaction was described as being very similar to that resulting from the injection of typhoid vaccine. The reaction, however, did not appear in the majority of cases till after the second day. This was occasionally delayed till even the tenth day. No reaction was reported in 8 per cent, of the cases. In a few cases the reaction was marked,

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