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Article
February 28, 1920

SOME FACTORS IN BONE REPAIR

JAMA. 1920;74(9):604. doi:10.1001/jama.1920.02620090034011
Abstract

In the process of the bone repair which follows fracture and other injury of the osseous system, there is frequently considerable débris to be eliminated, such as blood clots, injured bone fragments and other damaged tissue. In addition to this necessity in the early stages of the reparative process, at a subsequent stage the preliminary or primitive new structure must in part be removed to give place to true bone. The excess of the provisional callus which is organized in connection with a bone injury as a rule gradually disappears, so that, as in the course of bone growth, bone resorption is likewise an active process in the later stages of bone repair. Osteoblasts are concerned first of all in the formation of primary bone from calcified cartilage. Until quite recently, it has been assumed that the so-called osteoclasts, which function in the formation of the large central marrow cavities

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