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March 13, 1920


JAMA. 1920;74(11):733-734. doi:10.1001/jama.1920.26210110001007

Many requests have been received for information as to the practical application of this method of administering digitalis, and therefore it seems advisable to publish a brief statement regarding the details involved. The reader is referred to the original paper1 for the data on which the method is based, and to the papers by S. Marx White and R. Edwin Morris,2 and by R. Edwin Morris,3 for comments on the method.

This method of digitalis dosage and administration is designed especially for rapid digitalization by oral administration. It depends on the establishment of an average total amount of digitalis which is required to produce full digitalization, or the minor toxic actions of digitalis. This total amount is expressed in terms of the activity of the drug and the patient's body weight in pounds. The activity of the drug is determined by the cat method of Hatcher,4

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