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—Miss M. A., aged 48, a suit saleswoman, whose family history was unimportant except that a maternal aunt had died of tuberculosis, and whose habits were good, noticed, in April, 1919, that her feet burned constantly during the day and that she felt tired. Two weeks later she had a sense of numbness in both feet, and in the legs as far as the waist, and had some difficulty in walking. When I first saw the patient, September 12, she was confined to bed because she said she could not walk alone. She complained of numbness in the lower limbs, slight nausea for the preceding two days, constipation, and a severe pain in the lumbar region and legs whenever she moved. She said she had a sensation of something's turning over in the abdomen.
—The patient was a well nourished, somewhat obese woman. She lay quietly in
Redwood FH. COMBINED SCLEROSIS DUE TO ANEMIA OF THE PERNICIOUS TYPE: REPORT OF CASE. JAMA. 1920;74(15):1025. doi:10.1001/jama.1920.26210150002013b