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Comment & Response
April 21, 2015

Surgical Treatment for Drug-Resistant Epilepsy

Author Affiliations
  • 1Retired, Vigo, Spain
  • 2Complexo Hospitalario Universitario de Vigo, Vigo, Spain

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;313(15):1572. doi:10.1001/jama.2015.2883

To the Editor Drs Jobst and Cascino1 emphasized the low number of referrals for epilepsy surgery despite the good outcomes obtained in 2 high-quality randomized clinical trials (RCTs) that compared surgical treatment with pharmacotherapy in patients with temporal lobe epilepsy. But in one RCT, recruitment of patients who had experienced treatment failure with only 2 antiepileptic drugs was so problematic that the trial was halted.2 Enrollment was complete in the other RCT of patients who had experienced treatment failure with 6 antiepileptic drugs.3

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