In Reply Dr Violi and colleagues raise the possibility that an association between hospitalization for pneumonia and subsequent increase in CVD risk may be confounded by differential use of aspirin prior to the occurrence of pneumonia. We did not include aspirin usage because it was missing in 11% to 40% of participants at various time points during the first 10 years of follow-up in the CHS. The Table shows aspirin use based on data collected at baseline and at additional time points prior to hospitalization for pneumonia if these data were available. Aspirin use was similar between the 2 groups, suggesting that confounding by unaccounted aspirin use is unlikely.
Corrales-Medina VF, Alvarez KN, Yende S. Hospitalization for Pneumonia and Risk of Cardiovascular Disease—Reply. JAMA. 2015;313(17):1753-1754. doi:10.1001/jama.2015.3133