In Reply Dr Remy is concerned that null findings of the RESTORE clinical trial may have been the result of the cluster randomized design leading to variation in sedation assessments between bedside nurses and among different centers. Remy asks whether measures of variation between bedside nurses were determined prior to the study, whether additional sedation measures were considered, and whether nurse turnover or experience could have confounded study results.
Curley MAQ, Wypij D, Matthay MA, for the RESTORE Study Investigators. Sedation Protocol for Critically Ill Pediatric Patients—Reply. JAMA. 2015;313(17):1754-1755. doi:10.1001/jama.2015.3462