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Comment & Response
May 5, 2015

Sedation Protocol for Critically Ill Pediatric Patients—Reply

Author Affiliations
  • 1School of Nursing, University of Pennsylvania, Philadelphia
  • 2Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
  • 3School of Medicine, University of California, San Francisco
JAMA. 2015;313(17):1754-1755. doi:10.1001/jama.2015.3462

In Reply Dr Remy is concerned that null findings of the RESTORE clinical trial may have been the result of the cluster randomized design leading to variation in sedation assessments between bedside nurses and among different centers. Remy asks whether measures of variation between bedside nurses were determined prior to the study, whether additional sedation measures were considered, and whether nurse turnover or experience could have confounded study results.

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