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Medical News & Perspectives
May 5, 2015

Unraveling the Influence of Gut Microbes on the Mind

JAMA. 2015;313(17):1699-1701. doi:10.1001/jama.2015.2159

Within the last decade, the phrase “gut feelings” has taken on a whole new meaning. Traditionally, scientists have focused on the role of the central nervous system in regulating our moods and behaviors, but a paradigm shift is afoot, with new research revealing a unique role of our gut microbiota in influencing emotion.

A seminal study published in 2004 provided some of the first evidence of bidirectional interaction between gut bacteria and the brain, demonstrating that germ-free (GF) mice without commensal microorganisms have an exaggerated response to stress, accompanied by altered brain chemistry and elevated stress hormones, which could be normalized by administration of a single type of bacterium, Bifidobacterium infantis (Sudo N et al. J Physiol. 2004;558[pt 1]:263-275).

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