In Reply Dr van Zanten asks about other infection prevention strategies and adherence in our pragmatic, cluster-randomized, crossover trial testing the effectiveness of chlorhexidine bathing on health care–associated infection rates. The intervention was layered on routine care, which included numerous infection control practices such as hand washing, chlorhexidine oral solution for intubated patients, and chlorhexidine skin cleansing prior to central venous catheter insertion.
Noto MJ, Rice TW, Wheeler AP. Chlorhexidine Bathing and Infections in Critically Ill Patients—Reply. JAMA. 2015;313(18):1863-1864. doi:10.1001/jama.2015.3539