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JAMA Clinical Challenge
May 19, 2015

Iris Heterochromia and Unilateral Eyelash Hypertrichosis

Author Affiliations
  • 1W. K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor
  • 2Department of Pathology, University of Michigan, Ann Arbor
  • 3Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor
  • 4Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston
JAMA. 2015;313(19):1967-1968. doi:10.1001/jama.2015.1348

An 87-year-old woman with a history of open-angle glaucoma in her right eye presented with longer, thicker eyelashes on the right side compared with the left. Her irises were also different colors: the right iris was brown, and the left was hazel (green-brown) (Figure 1). The patient had noticed a gradual darkening of her right iris and lengthening of her eyelashes during the last year but denied visual changes or foreign-body sensation. Her medical history included a cerebrovascular accident, hypercholesterolemia, and hypertension and a remote history of breast cancer treated with lumpectomy and radiation therapy. Her medications included bimatoprost, atenolol, atorvastatin, and clopidogrel.

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