To the EditorClostridium difficile infection is a common, serious diarrheal illness, and strains such as the virulent North American pulsed-field gel electrophoresis type 1 make treatment challenging. The meta-analysis1 summarizing the available treatment options for incident C difficile infection in adults recommended vancomycin with or without adjunctive therapy as the treatment of choice for severe, complicated infections and metronidazole for milder disease.
McDonald EG, Lee TC. Treatment for Clostridium difficile Infection in Adults. JAMA. 2015;313(19):1974-1975. doi:10.1001/jama.2015.3668