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Two large recently published trials demonstrate that alternative antibiotic regimens given outside the hospital in developing countries can be used effectively to treat newborns and young infants who have severe infections and whose parents refused hospital referral or admission.
The World Health Organization recommends that infants aged between 0 and 59 months with possible serious bacterial infections be treated in the hospital with injectable antibiotic therapy for at least 7 to 10 days. But in many cases, referral to a hospital is not possible or acceptable to families because of transportation, cultural, or financial issues.
Friedrich M. Simplified Antibiotic Regimens for Infants With Severe Infections. JAMA. 2015;313(19):1897. doi:10.1001/jama.2015.4784