To the Editor In the PROPPR study,1 mortality was not statistically different between groups transfused with plasma, platelets, and RBCs in a 1:1:1 ratio compared with a 1:1:2 ratio. This lack of difference in mortality may be explained by the high rate of death related to traumatic brain injury (one-third of deaths), which could dilute the main effect of the transfusion intervention; and also by the large effect size that the study was trying to detect (10%).
Helwani MA, Gillihan JR. Mortality and Ratio of Blood Products Used in Patients With Severe Trauma. JAMA. 2015;313(20):2078. doi:10.1001/jama.2015.4424