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Clinical Trials Update
May 26, 2015

Intervention Boosts Cognitive Scores in People at Risk for Dementia

JAMA. 2015;313(20):2015. doi:10.1001/jama.2015.5169

An intensive, multidomain prevention program appears to have slowed down cognitive decline in elderly people in a proof-of-concept trial conducted in Finland (Ngandu T et al. Lancet. doi:10.1016/S0140-6736(15)60461-5 [published online March 11, 2015]).

The study randomly assigned 1260 people aged 60 to 77 years to an intervention group or a control group (1:1). All study participants were at risk of dementia based on standardized test scores. The intervention group met regularly over 2 years with physicians, nurses, and other health professionals and received a specific diet to follow, exercise training led by physiotherapists, group and individual cognitive training provided by psychologists and web-based programs, and social activities simulated through the many group sessions attended by participants. The control group received general health advice on eating healthy and participating in physical, cognitive, and social activities.

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