[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.129.96. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 632
Citations 0
Lab Reports
June 2, 2015

Targeting Insulin Pathways to Treat Brain Tumors

JAMA. 2015;313(21):2114. doi:10.1001/jama.2015.5140

By using computer models and conducting experiments on 2 different glioblastoma cell types, investigators from Rice University, in Houston, have shown how insulin signaling activity relates to brain tumor growth (Lin KW et al. PLoS Comput Biol. 2015;11[4]:e1004169).

By testing contributions of different insulin signaling protein interactions, the team found that feedback from insulin-like growth factor binding protein 2 (IGFB2) to a transcription factor known as hypoxia inducible factor 1α (HIF-1α) is integral to sustained growth of glioblastoma, whereas signaling from insulin-like growth factor 1 (IGF-1) to HIF-1α, which has been the target of many insulin signaling drugs in clinical trials, plays a less important role in tumor growth.

First Page Preview View Large
First page PDF preview
First page PDF preview
×