No one may now question the great influence of the glands of internal secretion on important physiologic processes. The growth of the body, the proper development of the nervous system, the appearance of secondary sex characters, the orderly sequences in the reproductive cycle, the nature and rate of chemical changes in the body—all these fundamental processes seem to be in the grip of the endocrine organs. Agents which can determine whether an individual shall be a giant or a dwarf, an idiot or a normally intelligent person, a "sissy" or a real male, a bearded lady or a woman; agents which are essential to normal metabolism—indeed, whose destruction may lead promptly to death—must evidently be respected.
There appears to be a tendency just now, however, to pay these glands not only respect, but reverence and homage and a blind worship. The endocrine organs are referred to as "regulators of metabolism"
CANNON WB. SOME CONDITIONS CONTROLLING INTERNAL SECRETION. JAMA. 1922;79(2):92-95. doi:10.1001/jama.1922.02640020004002