Little more is known of the origin and nature of cancer than was known many years ago. Clinical considerations and experimental observations have accumulated which have enriched the literature of this subject, but the incidence of cancer increases. Although this is both appalling and true, there is, nevertheless, reason to believe that, out of the spirit of sacrifice and the genius of persistence of the laborers in this field of research, a solution will come eventually. The united efforts of pathologists, clinicians, statisticians and general practitioners will finally unravel the mystery of cancer, and probably through the study of the four factors of incidence, heredity, agency of transmission and pathology.
It is perhaps to the experiments of the laboratory that we look with the greatest confidence; but the clinical notations of the physician and surgeon who deal with cancer in man must be deemed of interest and importance.
EASTMAN JR. PROPHYLAXIS OF MALIGNANT GROWTHS OF THE MOUTH, FACE AND JAWS. JAMA. 1922;79(2):118-120. doi:10.1001/jama.1922.02640020030008