[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.140.252. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 12, 1922

EFFECT OF REPEATED ADMINISTRATION OF ANESTHETICS ON BLOOD CATALASE

Author Affiliations

URBANA, ILL.

From the physiologic laboratory, University of Illinois.

JAMA. 1922;79(7):545. doi:10.1001/jama.1922.02640070033010
Abstract

We had already found that anesthetics produce a decrease in catalase, an enzyme possessing the property of liberating oxygen from hydrogen peroxid, and accordingly suggested that this decrease in catalase with resulting diminution in oxidation might be responsible for anesthesia. It was also found that a strong anesthetic, such as chloroform, produced a much greater decrease in catalase than a weaker anesthetic, such as ether, and that a rapidly acting anesthetic, such as nitrous oxid, decreased catalase more rapidly than a more slowly acting one.

The object of the present investigation was to determine the effect of repeated administrations of anesthetics on the blood catalase. The animals used were rabbits, and the anesthetics chloroform and ether. Catalase determinations were made by adding 1 c.c. of the rabbit's blood, diluted 1: 3 with 0.9 per cent. sodium chlorid, to neutral hydrogen peroxid, and the amount of oxygen liberated in ten minutes

First Page Preview View Large
First page PDF preview
First page PDF preview
×