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August 12, 1922


JAMA. 1922;79(7):558-559. doi:10.1001/jama.1922.02640070046017

In the conventional discussions of the physiology and pathology of the body, only scanty attention is usually paid to the lymphatic system. This is perhaps due to the fact that the latter does not obtrude itself so conspicuously as does the blood vascular system for observation; in part it is due to the lack of information regarding the "middleman" between the blood and tissues, and the spaces within which the lymph is confined. From the standpoint of nutrition and cellular function, the significance of the lymphatic system becomes emphasized by the fact that in no part of the body does the blood come into direct contact with the tissue cells, for it is confined in vessels with distinct walls. The exchange of materials—food products and waste substances—goes on through the intermediation of extravascular fluids. Some of these are contained in the tissue spaces, others in what is now regarded as

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