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September 9, 1922


JAMA. 1922;79(11):898. doi:10.1001/jama.1922.02640110038012

It has become increasingly more difficult in recent years for the clinician to find his way through the tortuous maze of conflicting opinions regarding the functions and potency of epinephrin in the organism. The epoch-making discovery of Oliver and Schäfer in England a quarter of a century ago that extracts of the suprarenal glands have a powerful action as cardiovascular stimulants directed attention to this phenomenon, a truly remarkable manifestation of pharmacologic action, to the almost complete exclusion of other considerations of possible suprarenal function. The presumable untenability of the long-fostered belief that effective blood pressure and a stimulative influence on the sympathetic nervous system are maintained by continuous discharge of the active principle epinephrin into the circulation has repeatedly been referred to in The Journal.1 In a similar category of undemonstrated beliefs belongs the conclusion that the profound asthenia attending destruction of the suprarenal tissues is due to

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