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September 16, 1922


Author Affiliations

Director, International Health Board BANGKOK, SIAM

JAMA. 1922;79(12):964-965. doi:10.1001/jama.1922.02640120038013

For many years thymol has had a deserved repute as a relatively safe and efficient anthelmintic drug. In the numerous campaigns conducted for the relief and control of hookworm infestation it has been extensively, and in some campaigns exclusively, employed. The number of doses administered in these campaigns, as reported, probably surpasses one and a half million. In the limited literature available' to me for reference, I can find reports of less than twenty fatalities. No doubt fatalities occur which are not reported, but the total number must be exceedingly small. During experience in antihookworm work in Ceylon, Java and Siam and covering a period of six years, I myself have known of only three deaths which were even remotely connected with the administration of thymol. One of these fatal cases occurred in Ceylon, when a planter forgot instructions and administered a liberal dose of brandy to a coolie who

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