For many years, gastric analysis has been a procedure utilized by physicians as an aid in the diagnosis of gastric disorders. Introduced to the profession in a practical way about 1870, it has been used more or less generally ever since. In its early history the analysis was not extensive, aiming chiefly to determine the degree of acidity. Later, attention was also given to the estimation of pepsin or peptic activity. Somewhat later, more extensive analyses were made, of which that of Hayem and Winters is typical, but they were not practical, and except in the more completely equipped laboratories could not be satisfactorily made. Following this, the tendency was toward simplification, until the only result of the analysis considered by the clinician was the degree of total and free acidity at about one hour following the injection of the test meal. Macroscopic and microscopic examinations were largely neglected.
EGGLESTON EL. GASTRIC SECRETORY DISTURBANCES. JAMA. 1924;83(4):260–265. doi:10.1001/jama.1924.02660040030010