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August 2, 1924


JAMA. 1924;83(5):373. doi:10.1001/jama.1924.02660050059021

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The Significance of Hormones in the Pathogenesis and Therapy of Rickets  In No. 27 of the Deutsche medizinische Wochenschrift, Vollmer reports the results of his investigations, conducted in the Kaiserin Auguste Victoria Haus in Berlin, on the significance of hormones in the pathogenesis and therapy of rickets. Vollmer was able to establish that the suprarenals, the hypophysis, the thyroid gland, the thymus and the ovary reduce materially acid elimination by the urine and accelerate intermediary metabolism, whereas the parathyroid glands exert an antagonistic action. Epinephrin showed a two-phase action. The first phase, which is associated with an increased acid elimination, is, according to his own findings and also the findings of other authors, characterized by a decrease in phosphorus and potassium, an inconstant increase in calcium and a hyperglycemia, whereas the second, alkalotic, phase is marked by an increase in phosphorus and potassium, a decrease in calcium and hypoglycemia. The

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