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The author observed a unique case of alopecia following the combined administration of roentgen rays and radium, subsequent to a Ries-Wertheim operation for cancer of the uterus. This alopecia entailed the entire loss of the capillitium, followed by complete return to health within a few months, although no special therapeutic efforts were employed. This case induced the author to make a study of the efficiency and untoward effects of radiotherapy. He reviews the theories concerning the physical action, on the tissues, manifested by therapeutic rays originating in the roentgen-ray tube and also from radioactive substances. He distinguishes in discussing untoward results the immediate effects—Roentgenkater—then destructive changes occurring several weeks after treatment, and finally very remote injuries that occasionally make their appearance in the intestine. The causes of those incidents and the means proposed for their prevention are mentioned and discussed. A comparative evalution of roentgen rays versus the
Gynäkologische Strahleneffekte und eine merkwürdige Alopecie.. JAMA. 1922;79(19):1633. doi:10.1001/jama.1922.02640190071043