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Under thorough infiltration of the skin and subcutaneous tissue extending one-half inch beyond the area affected, with 0.5 per cent. quinin and urea hydrochlorid solution, itching is at once arrested; excoriations rapidly heal, and within a few days the skin resumes its normal smoothness and luster. Anesthesia, however, persists for from several days to as many weeks, and, at the expiration of this period, a second and sometimes a third infiltration is or may be required. It has not been necessary to employ a fourth infiltration in any case thus far treated, as the causative factor is searched for, and, if found, eliminated during the days of freedom from itching produced by this simple measure. Occasionally, one injection suffices, and the patient remains away for months; but he finally returns to have skin tabs removed or other operative rectal procedure which he was told in the first instance would be
Moorer MP. TREATMENT OF PRURITUS ANI, VULVAE AND SCROTI. JAMA. 1924;83(10):766. doi:10.1001/jama.1924.26610100002012b