Positive assertions that hexamethylenamin acts as a diuretic have been made by Nicolaier,1 Lilienthal,2 Flexner,3 Impens4 and Seifert and Müller.4 Nicolaier reported that 1 gm. doses of the drug increase the output of urine. On the other hand, Thompson5 and Strauss and Seibert4 have denied the diuretic action of hexamethylenamin. The conclusions of all these authors are based almost exclusively on impressions, critical objective data being totally absent. A priori, it appears improbable that hexamethylenamin in small (1 gm.) and moderate doses could increase the urine output. Large doses could conceivably increase diuresis through a salt action, but this could not be attributed to any specific or peculiar property of hexamethylenamin. On the other hand, large doses might diminish the urine output because of renal injury, which has been declared by some to occur.
In connection with another study, we had an opportunity to
RUH HO, HANZLIK PJ. HEXAMETHYLENAMIN AS A DIURETIC. JAMA. 1922;79(24):1980-1982. doi:10.1001/jama.1922.02640240014006