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JAMA Clinical Evidence Synopsis
June 9, 2015

Nonsteroidal Anti-inflammatory Drugs for Treatment of Acute Gout

Author Affiliations
  • 1Department of Internal Medicine, Maastricht University Medical Center, the Netherlands
  • 2Centre Hospitalier Chrétien, Liège, Belgium
  • 3Rheumatology Research Unit, Repatriation General Hospital, Daw Park, Australia
  • 4Flinders University, Bedford Park, Australia
  • 5Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, the Netherlands
  • 6Department of Rheumatology, Atrium Medical Centre, Heerlen, the Netherlands

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JAMA. 2015;313(22):2276-2277. doi:10.1001/jama.2015.1881

Clinical Question  Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with better outcomes than cyclooxygenase inhibitors, glucocorticoids, IL-1 inhibitors or placebo in the treatment of acute gout?

Bottom Line  NSAIDs are not significantly associated with a difference in pain reduction compared with cyclooxygenase inhibitors and glucocorticoids for treating acute gout. However, NSAIDs are associated with higher rates of adverse events and higher rates of withdrawal due to adverse events compared with cyclooxygenase inhibitors.