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From the JAMA Network
June 9, 2015

Insulin Dosing in Pediatric Diabetic KetoacidosisWhere to Start?

Author Affiliations
  • 1Departments of Medicine and Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, Illinois
JAMA. 2015;313(22):2274-2275. doi:10.1001/jama.2015.135

The incidence of type 1 diabetes mellitus is increasing in pediatric populations.1 Although the degree of hyperglycemia and frequency of ketoacidosis at initial presentation of those with type 1 diabetes have steadily declined,2 diabetic ketoacidosis (DKA) remains the leading cause of death in children and young people (aged <24 years) with type 1 diabetes mellitus.3,4 Cerebral edema can be difficult to recognize and manage in children and represents the major cause of the continued mortality and morbidity associated with DKA in this population.4

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