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Comment & Response
June 9, 2015

Varenicline for Smoking Reduction Prior to Cessation—Reply

Author Affiliations
  • 1Mayo Clinic, Rochester, Minnesota
  • 2Department of Psychiatry, University of Vermont, Burlington
  • 3Health Behaviour Research Centre, University College London, London, England
JAMA. 2015;313(22):2285-2286. doi:10.1001/jama.2015.4981

In Reply Dr Cropsey and colleagues suggest that a carbon monoxide cutoff of 8 to 10 ppm or less may artificially inflate smoking abstinence rates and that a cutoff of 3 to 4 ppm or less may be more appropriate for determining abstinence in clinical trials in which smoking abstinence is the goal. For the current study, we used the recommendations of the expert panel convened by the Society for Research on Nicotine and Tobacco for the biochemical confirmation of abstinence.1

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