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In Reply Dr Cropsey and colleagues suggest that a carbon monoxide cutoff of 8 to 10 ppm or less may artificially inflate smoking abstinence rates and that a cutoff of 3 to 4 ppm or less may be more appropriate for determining abstinence in clinical trials in which smoking abstinence is the goal. For the current study, we used the recommendations of the expert panel convened by the Society for Research on Nicotine and Tobacco for the biochemical confirmation of abstinence.1
Ebbert JO, Hughes JR, West RJ. Varenicline for Smoking Reduction Prior to Cessation—Reply. JAMA. 2015;313(22):2285-2286. doi:10.1001/jama.2015.4981