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In Reply If midazolam remains the most prescribed sedative premedication, lorazepam ranks third for outpatient surgery and fourth for inpatient surgery.1 Midazolam and lorazepam both belong to the benzodiazepine class and share most of their indications. The PremedX study evaluated sedative premedication with lorazepam given orally 2 hours before surgery. Lorazepam was chosen over the more commonly used midazolam because, due to its shorter acting time, midazolam may not have been as potent as lorazepam upon arrival in the operating room.
Maurice-Szamburski A. Presurgery Sedation and Patient Experience—Reply. JAMA. 2015;313(23):2380-2381. doi:10.1001/jama.2015.5522