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November 1, 1924


JAMA. 1924;83(18):1433. doi:10.1001/jama.1924.02660180051018

In a recent issue of The Journal1 reference was made to the now indisputable relation of calcium to the symptoms that are observed after removal of the parathyroid glands. The tetany that ensues is accompanied by a lowered content of calcium in the blood; and the procedures that are successful in combating or averting the untoward manifestations of muscular irritability involve the possibility of restoring in some measure the calcium content to its normal level. There has also long been an impression on the part of certain investigators that tetany is the expression of the effect of toxins of either exogenous or endogenous origin. Various chemical products, such as ammonia, guanidin derivatives, amins, creatin and creatinin, have been designated from time to time as the noxious agents. A recent examination by Swingle and Nicholas 2 of the claims filed against these substances has failed to substantiate the production of

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