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February 1, 1930


JAMA. 1930;94(5):350-351. doi:10.1001/jama.1930.02710310046020

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Diphtheria Among Persons Vaccinated  Against the DiseaseAlthough marvelous results have been obtained from antidiphtheritic vaccination by the Ramon anatoxin, it cannot be denied that some cases of diphtheria develop in persons who have received this type of vaccination. Several cases have been reported by various physicians. The Société de pédiatrie, whose membership comprises the head physicians of the children's hospitals in Paris, recently devoted an interesting discussion to this question. Lereboullet and Gournay declared that such cases are very exceptional. Most of them occur in subjects who received only two injections of anatoxin in place of three, as Ramon prescribes. Lereboullet called attention to the significant fact that, in all the institutions in which he carried out a systematic vaccination, not a case of diphtheria has since been observed in any vaccinated person, although outbreaks of diphtheria have brought down many of the nonvaccinated. He concludes that vaccination, carefully

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