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In considering the therapeutic action of glands of internal secretion, one must distinguish between the action of gland preparations in a replacement sense, in which the preparation supplies a deficiency due to a disturbance of the function of the same gland, and the pharmacologic action of gland preparations on a person who has no evidence of disturbed function of the gland from which the preparation was obtained. An extreme example of the latter occurs in connection with the thyroid. Iodin may be obtained from the thyroid; this iodin would have the same therapeutic action as iodin in the same form from any other source, and no one would regard this as any more than the usual pharmacologic or therapeutic effect of the substance instead of thinking of it as in any way related to the internal secretion of the thyroid gland. In this way one must consider the therapeutic effect
CHRISTIAN HA. EPINEPHRIN AND SUPRARENAL GLAND IN INTERNAL MEDICINE. JAMA. 1924;83(20):1588-1589. doi:10.1001/jama.1924.26610200003012a